I think it'd be kinda like the Wilson/Amber relationship, which had House trying to break them up. This time it'd be Wilson.

Sometimes i feel like Wilson wants House and Cuddy to happen, but i think in the aftermath of the season finale he may feel quite upset that he is alone now whereas House has Cuddy (which i also think was one of the things he was thinking in the finale when he was in House's hospital room and saw Cuddy sleeping next to his bed).

ya i wonder what wilson was thinking when he saw cuddy holding house's hand in the hospital bed...

I agree pottergal, I think he will actually be jealous. I think while he is blaming House for Amber's death I think he will not think its fair that House is happy now. He will warn Cuddy about what she is getting herself into, warn her about the effects on her etc....but he'll like being the go-to person for Cuddy...at least I think he will!

Oh Wuddy, when will you see that you are meant to be?!

Before the season finale, I think he would secretly be pretty gutted. But having seen the events that have transpired, I don't think Huddy happening would affect Wilson.

I think he'd be happy with them, as long as they knew what they were getting into.

Wilson knows House in every which way possible. If they did get together, he would naturally tell Cuddy about the risks she could be taking getting herself involved with someone like House. Wilson would act like House's dad or something and like, lurk over his shoulder and protect both of them. Yeah, Wilson lost Amber, and maybe he hasn't really accepted that fact yet, but he would have to accept House and Cuddy whether he'd like it or not, cause House had accepted Amber. He owes him that much.